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William Horatio Powell was the epitome of the suave, urbane leading man throughout his stage and film career. Powell was born in Pittsburgh, Pennsylvania, on July 29, , but the family moved to Kansas City in His accountant father, Horatio Warren, and his mother, Nettie Manila Brady Powell, hoped that he would become a lawyer. Young William, however, was drawn to the theater and worked as an usher at an opera house in order to be around professionals.
Powell was active in theater at Central High School, where he landed a supporting role in a school production of The Rivals and was also a cheerleader. He was already determined to become an actor. Powell attended the University of Kansas for a short time in , but returned home with the intention of earning enough money to study acting in New York.
He was a classmate of Edward G. Robinson and Joseph Schildkraut at the school until his money ran out six months later. In he won a supporting role in Within the Law and toured with the play for nearly two years. In he married Eileen Wilson, a cast member, and they had a son, William David, before they divorced in He married Carole Lombard, the greatest of the female screwball comedians.
Two years later that marriage ended, and he began a much-rumored relationship with Jean Harlow.
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Lombard in turn married Clark Gable. Powell and Harlow were engaged when she died in Although he was a master of romantic comedy, Powell was no stranger to dramatic roles. He was one of the few actors to make a successful transition from silent movies to the talkies.